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EGCG and weight management

EGCG and weight management

Samavat H, Newman A, Wang R, Nutritional counseling J, Wu A, Managemsnt M. This is because green tea extract has been Understanding anti-depressant side effects linked to Understanding anti-depressant side effects fat burning, Extract data from websites during exercise. Annd, EGCG and weight management one study qeight reported activation of AMPK by EGCG in cultured cells and in liver tissues of mice, suggesting that the effects of catechins, including their anti-obesity and anti-cancer effects, are at least partially mediated by activation of AMPK Murase et al. Skip to main content. Liu C, Huang C, Huang L, Chen I, Chiu J, Hsu C. Green tea consumption is associated with reduced incident CHD and improved CHD-related biomarkers in the Dongfeng-Tongji cohort.

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Green Tea for Fat Loss: Health Benefits of EGCG- Thomas DeLauer

EGCG and weight management -

A typical cup of tea brewed from dried leaves yields about to mg of polyphenols, but only a small portion of that is EGCG, which is considered the most beneficial compound of the group. Numerous health effects have been attributed to EGCG, including weight loss -- but the research was conducted with such high concentrations of EGCG that you are unlikely to get enough from drinking green tea alone.

Fortunately, many supplement stores carry EGCG extracts, and many diet pills include EGCG extract as an ingredient. Research has shown that EGCG may help increase calorie burn and help the body use stored fat for energy, although the exact mechanism is unclear. A study at the University of Chicago showed that rats reduced their calorie intake by 60 percent after seven daily EGCG injections, allowing them to lose 21 percent of their body weight.

Researchers believe that the EGCG may alter the levels of "hunger hormones," thus reducing the appetite. The catch is that the rats were given an injection of EGCG, and the results were not as promising when the EGCG was given orally.

It is unclear whether the body may not absorb EGCG fully from the digestive tract, but if an oral extract didn't work, that leaves little hope for the lower concentrations provided by oral tea consumption. There is no established dose for EGCG, partly because the research has been all over the map.

Ronald Hoffman mentions a French study that found results using 90 mg of EGCG three times daily, while a study in the "Journal of the American College of Nutrition" found that twice-daily doses of mg reduced resting heart rate and blood glucose levels, but did not affect weight loss.

The University of Maryland Medical Center recommends up to mg per day of a standardized extract, but also recommends up to three cups of green tea per day to provide mg of polyphenols. Because EGCG is but a small part of the overall polyphenol content, you're more likely to get a high enough dose by using an extract.

The most successful research into EGCG and weight loss has used injections rather than oral administration. This is not practical for home use, so extracts are recommended over tea for having a higher EGCG concentration.

Long-term oral use may mimic the results of an injection, which means that EGCG is not a quick fix -- results may take time, and the EGCG supplement must be a part of an overall diet and exercise program.

All participants were randomly assigned to either placebo or GTE treatment. A random number between 0. Those given random numbers between 0. To ensure that the capsules looked and smelled identical, opaque capsules were used to contain either GTE or placebo cellulose. They were administered to the participants by a research assistant who was also blinded to the contents of the capsules.

Characteristics of all the participants at baseline are shown in Table 1. The GTE samples, extracted from dried green tea leaves, were procured from the Tea Research and Extension Station, Taiwan. It was manufactured by a standard procedure and came with a certificate of analysis.

The control group was given placebo which was pure microcrystalline cellulose. The participants were asked to take one capsule 30 min after meal, three times a day for 6 weeks in each stage. Daily intake of GTE compounds is listed in Table 2 , among which EGCG amounted to As Table 1 shows, reduction of LDL-C level between two different treatments was used as one of the major outcome measurements.

Additionally, plasma lipoproteins such as triglyceride, cholesterol, HDL-C and LDL, as well as hormone peptides of both groups were measured at the baseline, the 6th, 8th and 14th week after treatments.

All measurements were made 8—9 h after an overnight fast using standardized methods and were repeated throughout the trial. All the participants had their measurements done with their undergarments and a hospital gown.

A wall-mounted stadiometer was used to measure their height to the nearest 0. Waist circumflex WC was measured by the mid-way between the lateral lower rib margin and the iliac crest. The demographic data was collected simultaneously.

The obesity-related hormone peptides, including leptin, insulin, ghrelin, adiponectin, apolipoprotein Apo A1 and apolipoprotein B [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ] were measured by collecting blood samples in the morning after fasting for 8—9 h.

The leptin was measured by Millipore Human Leptin assay kit Millipore, St. Charles, MO, USA , using the I -labled human leptin antiserum with a sensitivity of 0. The ghrelin and adiponectin were identified by the same process as for leptin, with the only difference that I -labled antibodies were specific to ghrelin or adiponectin, using Ghrelin, and Adiponectin RIA kits Millipore, St.

The levels of insulin in serum were determined using BioSource INS-IRMA Kits BioSource Europe S. The respective coefficients of variation were 3. The parameter of sensitivity was 0.

Insulin resistance was indicated when HOMA-IR values exceeded 2. The Apo AI and Apo B levels of participants were detected by Immunoturbidimetric assay K-assay, Kamiya Biomedical Company, Seattle, USA. After filtrating the supernatant with a 0.

HPLC analysis used in this study was performed by a Hitachi series module equipped with a photodiode array detector and the wavelength was set at nm.

The flow rate of the mobile phase was 0. All the data was analyzed using SPSS software version 16, Chicago, IL. Student t -test was employed to examine the main outcomes, demographic data, and other measurements.

Paired t -tests were utilized to examine differences of subjects within groups at 0 to 6 weeks in stage 1 and weeks 8 to 14 in stage 2. All p values were two-tailed and the α level of significance was set at 0. Among all the data shown in Table 3 , most of the anthropometric data such as weight, body mass index, WC, and waist hip ratio were not significantly different between treatments in stages 1 and 2, by both paired or non-paired t -test.

Only the HC of Group B significantly decreased from In stage 1, fasting blood sugar and plasma lipoproteins of Group A did not change significantly.

In contrast, fasting blood sugar and adiponectin of Group B significantly decreased on the 42th day of treatment, only by the paired t -test. The fasting blood sugar means SD of Group B reduced from There was a significant 7. Except adiponectin, the hormone peptides of Group A and Group B were not significantly different after treatments in this stage.

The means SD of adiponectin increased from In stage 2, Group A was given placebo and Group B received GTE. Reductions were observed in several biomarkers, i. LDL, adiponectin, ghrelin and apolipoprotein B In Group B, LDL at this stage showed a 5. The adiponectin of Group A showed an In Groups A and Group B, ghrelin level significantly decreased, showing a reduction of There was also a 5.

The double-blind, placebo-controlled, cross-over design study showed that there were no statistical difference in the levels of BMI, fasting blood sugar, total cholesterol, triglyceride, high density lipoprotein, adiponectin and ghrelin etc.

between the GTE and placebo groups after treatments. However, it especially showed a significant Green tea consumption in the form of EGCG, GTE or catechins by subjects with high BMI may decrease body weight, BMI, waist and hip circumference and improve blood lipid profile, glucose homeostasis as well as decrease inflammatory markers.

However, the results are not consistent by showing either an improvement or no effect. Our study showed significant increase in leptin and decrease in LDL-C levels in patients who received GTE treatment. With an increase in obesity prevalence, many alternative treatments for weight control are developed [ 34 ].

Studies argued that GTE appeared to have anti-obesity and anti-diabetic effects. However, in this double-blind, placebo-controlled, cross-over design study, the results revealed that green tea extract with a high dose of EGCG was not able to produce a significant decrease in body weight, BMI or fasting blood sugar levels in obese Taiwanese women within the trial period although in many human studies there have been reported decrease in body weight and body fat [ 35 ].

GTE has shown to increase fat oxidation and energy expenditure due to its high concentration of EGCG [ 36 ]. EGCG inhibits catechol-o-methyltransferase COMT which is an enzyme that causes the degradation of norepinephrine. This in turns results in increased lipolysis and fat oxidation [ 37 ].

It has been suggested that the COMT single nucleotide polymorphism SNP rs is very common in Asians and alters sensitivity to EGCG, which leads to a greater energy expenditure and body fat loss due to more effective supplementation.

Therefore it is important to consider the ethnicity when conducting this kind of study as better results are obtained amongst the Asian population in comparison to Caucasians [ 38 ].

Furthermore, leptin has a role in regulating lipid metabolism as it stimulates fatty acid oxidation and decreases triglyceride stores within fat cells in the liver as well as inhibiting lipogenesis and stimulates lipolysis in fat cells [ 40 ].

Once leptin is released by the adipose tissue, it is secreted into the bloodstream and circulated in proportion to body fat mass [ 39 ]. There are several factors that influence the regulation of circulating leptin levels including food intake and glucose uptake which increase the levels of circulating leptin while exercise and increased age decrease the levels of circulating leptin [ 41 ].

Leptin crosses the blood-brain barrier and activates the leptin receptor, which causes an inhibitory effect on associated insulin stimulated metabolic pathways. Therefore treating adipocytes with leptin reduces insulin stimulation of carbohydrate and lipid metabolism as well as insulin stimulation of protein synthesis.

Previous studies have found that leptin suppresses the LDL receptors LDL-R through the repressed expression of the SREBP2, which is a transcription factor of LDLR gene [ 39 ].

The LDLR gene is responsible for the production of LDL-R, which binds LDL particles. LDL primarily carry cholesterol in the blood. LDL-R binds to LDL circulating in the bloodstream and transports them into the cell. The LDL are broken down and the cholesterol is released.

LDL-R are critical in regulating the amount of cholesterol in the blood [ 42 ]. Our study showed that there was a significant decrease in LDL levels after GTE consumption.

It is consistent with a previous study that showed green tea decreasing absorption of lipids and proteins in the intestine and also activating the pathway to decrease gluconeogenesis and fatty acid synthesis [ 43 ]. It is, however, suggested that disruption of leptin receptors have no significant impact on target organs because its main effect is on the brain that then has the effect on glucose and lipid metabolism [ 44 ] and thus this study suggests that GTE is the main cause of the lowering of LDL levels.

There has been similar studies done in the past to determine whether green tea extracts have been advantageous in improving various biochemical markers related to obesity but this is one of the few studies that is designed with a crossover.

This allows for accurate comparisons of biochemical markers within the same individuals during stages 1 and 2. Each individual serves as his or her own control, therefore decreasing the variability between the individuals.

It is therefore not necessary to make any adjustments to variables such as dietary intake, levels of physical activity or post-menopausal changes. At the commencement of the trial, individuals were also instructed to follow their previous dietary habits throughout the course of the study as stated in the Method section.

Another advantage of this crossover study is that it requires a smaller sample size compared to previous studies such as Samavat et al. With a smaller sample size, there runs a risk of participants withdrawing leaving little data to be analyzed.

This study presents with several limitations. Firstly, the short duration of the study might not have allowed sufficient time for significant changes to take place.

When compared with previous studies such as Samavat et al. In retrospect, a study by Li [ 47 ] suggests that noticeable effects of tea only occur after 8 or more weeks of intervention. Even though participants were only exposed to GTE for 6 weeks, it caused a noticeable change in leptin and LDL levels.

Secondly, the gender and ethnical limitations render this study not applicable to all persons of the general population. This study shows that green tea extract effectively increases leptin and reduces LDL in women after 6 weeks of treatment even though there were no significant changes in other biochemical markers related to overweight such as total cholesterol, triglyceride, and BMI.

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We EGCG and weight management your Heart health education and advocacy. All email addresses you provide will be used just for weighht this story. Green tea weighg long been consumed EEGCG its health properties. Along with its ability Understanding anti-depressant side effects boost mental alertness, the beverage has been said to burn fat, and potentially to protect against heart disease and cancer. Claims like these are what draw consumers to supplements made from green tea extract, which is now a common ingredient in weight loss or fat burning supplements. And tea itself, including green tea, is the most commonly consumed beverage in the world aside from water. EGCG and weight management

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