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Green tea and diabetes

Green tea and diabetes

There was no statistically Gren difference in Green tea and diabetes concomitant medication between Diabetic foot safety two groups. A Liver health support published in the Journal of Tez in Grreen Green tea and diabetes looked at different doses of green tea in 63 Tsa with type 2 diabete. Next, Bruno and other researchers are Green tea and diabetes to dive more fiabetes how diagetes tea affects the diahetes in the gut to hopefully discover if green tea can boost good bacteria while helping to decrease the amount of not-so-beneficial bugs in the gut. The team conducted the clinical trial in 40 individuals as a follow-up to a study that associated lower obesity and fewer health risks in mice that consumed green tea supplements with improvements to gut health. Best Oils for Skin Complementary Approaches Emotional Wellness Fitness and Exercise Healthy Skin Online Therapy Reiki Healing Resilience Sleep Sexual Health Self Care Yoga Poses See All. This trial enrolled 92 subjects with type 2 diabetes mellitus and lipid abnormalities randomized into 2 arms, each arm comprising 46 participants. Green tea and diabetes

Green tea and diabetes -

Relevant English-language articles were identified via searches in PubMed, Embase, and the Cochrane Library from the index date of each database through February Additional studies were identified by manually screening the reference of originally identified reviews and research reports or the clinical trials.

The search was confined to studies involving humans. The data from multiple published reports involving the same study population were included only once.

Two review authors CGZ and XRF independently assessed the study quality and any disagreement was resolved by discussion between the third author YK.

Jadad scoring criteria was used in which a study was judged on 0—5 points 5 reflected the highest quality. With this system, one point was allocated to each for 1 randomization; 2 double blinding participant and researcher masking ; 3 reporting the number of and reasons for withdrawal; 4 generation of random numbers; and 5 allocation concealment.

Two authors CGZ and XRF independently extracted the data, and any discrepancies between the two reviewers were resolved through discussion with a third author BY. The following information was recorded using a standardized electronic form: study characteristics the first author, publication year, study design, study duration, sample size, intervention type, and dosage , population information age, sex, country, and baseline fasting glucose , and baseline and final concentrations or net changes of FBG, FBI, HbA1c and homeostatic model assessment of insulin resistance HOMA-IR.

Studies with multiple dosages of green tea or multiple control groups were included separately in the meta-analysis. A meta-analysis was performed with the use of the STATA statistical software version 11; STATA Corp LP. For parallel trials, the treatment effects were calculated as the weighted mean difference WMD and standard deviation SD in the change from baseline to follow-up in the green tea group versus control group.

For crossover trials, the treatment effects were calculated as the WMD and SD at follow-up in the green tea intervention versus control periods. In addition, missing SD values for paired differences were imputed by assuming a correlation coefficient of 0.

Random-effects models DerSimonian and Laird , which considered both within- and between-study variation, were performed for the studies used different doses, different populations, different durations and so on [ 20 ].

Primary outcome measures included WMD in FBG, FBI, and HbA 1c after green tea supplementation. The secondary outcome measures included WMD in HOMA-IR concentration. Sensitivity analyses were used to evaluate the stability of the results by removing a single study each time to identify the effect of individual studies on the pooled effect size.

Meta-regression analysis was performed to examine the association between the net change in fasting glucose, fasting insulin or HbA 1c and intervention dose, treatment duration, intervention type, caffeine content, different ethnicity or study design.

The search strategy identified abstracts. After the titles and abstracts were screened, articles were excluded and 95 articles underwent full-text review.

A further 68 articles were excluded for the following reasons: 26 articles did not provide relevant outcomes, 14 articles involved green tea as a multicomponent supplement in the experimental group, 12 articles were excluded because the subjects had been treated with black tea or oolong tea.

Finally, 27 eligible articles met the inclusion criteria and were included in the meta-analysis Fig. Table 1. Of the 27 trials with 28 comparisons included in the current meta-analysis, 13 comparisons [ 22 , 23 , 24 , 25 , 28 , 29 , 30 , 33 , 36 , 39 , 46 , 48 ] were conducted in western countries and 15 comparisons [ 26 , 27 , 31 , 32 , 34 , 35 , 37 , 38 , 40 , 41 , 42 , 43 , 44 , 45 , 47 ] were conducted in Asian countries.

Twenty comparisons [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 33 , 36 , 38 , 39 , 41 , 42 , 45 , 46 , 47 , 48 ] were performed in subjects with normal FBG and 8 comparisons [ 31 , 32 , 34 , 35 , 37 , 40 , 43 , 44 ] were performed in subjects with high level FBG.

Most comparisons 25 of 28 used a parallel study design [ 22 , 23 , 24 , 26 , 27 , 28 , 29 , 30 , 31 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 45 , 46 , 47 , 48 ], while others 3 comparisons used a crossover design [ 25 , 32 , 44 ].

Twelve comparisons [ 22 , 24 , 25 , 27 , 29 , 33 , 35 , 37 , 38 , 39 , 48 ] adjusted for the confounding effect of caffeine on glucose and insulin, 13 comparisons [ 26 , 28 , 30 , 31 , 32 , 34 , 36 , 40 , 41 , 42 , 43 , 44 , 45 ] used caffeinated green tea, and 3 [ 23 , 46 , 47 ] did not report the use of coffee.

Twenty comparisons [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 46 , 47 , 48 ] used green tea extract capsule and eight comparisons [ 22 , 31 , 32 , 41 , 42 , 43 , 44 , 45 ] used green tea beverage Table 1.

The study quality of the 27 included RCTs varied. Most trials did not report details regarding allocation concealment 14 of 27 [ 26 , 28 , 30 , 31 , 32 , 36 , 37 , 40 , 41 , 42 , 43 , 44 , 46 , 48 ] or randomization method 15 of 27 [ 23 , 28 , 30 , 31 , 32 , 33 , 36 , 37 , 40 , 41 , 42 , 43 , 44 , 45 , 48 ].

Twenty-two trials used double-blinded design [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 45 , 46 , 47 , 48 ], one trial used a single-blinded design [ 22 ], and four trials used an open-label design [ 31 , 32 , 33 , 44 ].

Three trials did not report the dropout rate or the reasons for the dropouts [ 28 , 40 , 44 ] Table 2. Primary outcome measures included changes in FBG, FBI, and HbA 1c.

Meta-analysis of the effects of green tea on fasting blood glucose concentrations. Meta-analysis of the effects of green tea on fasting blood insulin concentrations. Meta-analysis of the effects of green tea on HbA lc concentrations. Secondary outcome measures included changes in HOMA-IR concentration.

Green tea supplementation had no significant effect on HOMA-IR WMD: In the subgroup analysis, green tea consumption significantly lowered FBG concentrations in subjects using green tea capsule or with high catechins dosage, subjects from western countries, subjects in short duration of green tea supplementation, subjects with normal FBG, studies with caffeinated green tea intake, studies with parallel design, and studies with low quality.

However, significant reduction in fasting glucose was not found in other subgroups. In addition, the beneficial effect for green tea supplementation on fasting insulin was observed in subjects with green tea capsule, subjects from western countries, subjects with normal baseline FBG and studies with decaffeinated green tea intake.

However, no effect was found in other subgroups. Significant reductions in HbA 1c concentrations were observed in subjects from Asian countries, studies with caffeine in green tea and studies with low quality, while the obvious effect was not found in other subgroups Table 3. Meta-regression found no linear relations between WMD in FBG, FBI or HbA 1C and intervention dose Fig.

Furthermore, meta-regression found no linear relations between WMD in FBG or FBI and treatment duration, caffeine content, different ethnicity, intervention type and study design.

a Relation between the WMD of FBG and intervention dose in 27 independent randomized controlled comparisons. b Relation between the WMD of FBI and intervention dose in 18 independent randomized controlled comparisons. c Relation between the WMD of HbA lc and intervention dose in 11 independent randomized controlled comparisons.

Each circle represents a study, telescoped by its weight in the analysis. The funnel plots of the studies were symmetrical for fasting glucose, fasting insulin, and HbA 1c Supplementary Figure 1.

A sensitivity analysis was performed to confirm the robustness of our findings. The result was consistent after removing each trial for both fasting glucose and fasting insulin. In the sensitivity analysis of HbA 1c , the exclusion of one trial [ 22 ] Basu resulted in significant reductions of However, there was no significant reduction in HbA 1c after the removal of other trials.

This meta-analysis involving 27 RCTs with subjects evaluated the effect of green tea supplementation on glycemic control. We found that green tea supplementation significantly reduced FBG concentration, while the effect of green tea on other glycemic variables such as FBI, HbA 1c , and HOMA-IR was not significant.

Our results are consistent with some previous meta-analysis [ 49 , 50 ], which also showed that green tea consumption resulted in a significant reduction in FBG. While, another previous meta-analysis [ 8 ] suggested that green tea consumption had favorable effects on decreasing both FBG and HbA 1c concentrations.

In our study, we did not find a significant improvement in HbA 1c concentrations. Observational prospective cohorts and case-control studies have been performed to determine the effect of green tea supplementation on glycemic control, although the results are conflicting.

Some RCTs also found beneficial effects on glycemic control, including reducing fasting glucose and fasting insulin [ 38 , 48 ]. In contrast, several RCTs have reported no significant correlations between green tea intake and glycemic control [ 24 , 27 ].

Nonetheless, these results need to be interpreted with caution because the number of patients enrolled in most trials was too limited, at less than patients; in addition, the intervention duration and catechins dosages were varied among studies.

So, more RCTs with larger subjects and longer duration were needed to find out the real relationship between green tea consumption and blood glucose control. Recent mechanistic studies have examined the effects of green tea consumption on glucose control and provided further evidence for the biological plausibility of these findings.

Green tea may affect glucose control through different mechanisms. First, tea catechins have been reported to reduce carbohydrate absorption from the intestine via inhibition of intestinal sucrose, alpha-amylase, and alpha-glucosidase [ 10 ]. Second, Tea catechins might also inhibit the hepatic gluconeogenesis through regulation of the expression of gluconeogenic genes and protein-tyrosine phosphorylation in the mouse liver [ 52 ].

Third, tea catechins could enhance insulin sensitivity and glucose metabolism there by helping to prevent the development of T2DM [ 53 ].

Furthermore, Tea catechins are also powerful antioxidants that can ameliorate oxidative stress [ 54 ]. In this meta-analysis, subgroup analyses were performed based on predefined variables to identify potential sources of heterogeneity.

Green tea consumption significantly decreased FBG and FBI only in subjects using green tea capsule. In addition, meta-regression also pointed out that green tea capsule was associated with HbA 1C.

Nowadays, there was still insufficient evidence on whether green tea capsule was more biologically active compared to green tea beverage in vivo or vitro studies. In addition, subgroup analyses revealed that green tea with caffeine had a more pronounced effect on FBG and HbA 1C than the decaffeination subgroup.

As tea naturally contains caffeine in addition to catechins and other compounds, whether caffeine intake influences the glucose control of tea remains controversial [ 55 , 56 ]. As there were a limited number of subjects in the subgroup analysis, these results may not be generalized.

Our study had several strengths. First, we only selected RCTs in this meta-analysis, which ensured a relatively high-quality and provided reliable inference about causality.

Second, both parallel and crossover studies were included in this meta-analysis. Crossover trials are generally considered to have a more-robust design than parallel trials because of reduced intraparticipant variability.

We considered it important to include all these studies because they represented a comprehensive evidence for our analysis. Third, results were less likely to be influenced by publication bias.

Furthermore, subgroup analyses were undertaken to detect potential sources of heterogeneity for primary outcomes. Our study also had several limitations. HbA 1c is an important indicator for glucose control, including greater pre-analytical stability, greater convenience, and less day-to-day perturbations.

In addition, it also takes a number of months to detect delayed effects of green tea on insulin resistance. In addition, we could not ascertain the safety margin in this meta-analysis because no serious side effects were reported in the included trials.

However, mild side effects such as mild skin rashes, gastric disturbances, and abdominal bloating were reported in some clinical studies [ 57 ]. Third, the size of these trials, which ranged between 25 and participants, were indeed limited.

Therefore, our meta-analysis may have been underpowered to detect a true effect. Forth, the quality of RCTs included in this meta-analysis varied. Some of the RCTs did not provide detailed randomization process.

Of the 27 trials, almost half of the trials were of high risk of bias, which may also affect the reliability of our findings. In conclusion, green tea intake had a favorable effect on fasting blood glucose concentration.

However, green tea intake did not significantly affect fasting blood insulin or HbA 1c. In future, high-quality larger RCTs with long-term follow-up are needed to investigate the effect of green tea supplementation on glycemic control, especially the long-term effects on fasting insulin and HbA 1c.

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Evid Based Complement Alternat Med. PubMed PubMed Central Google Scholar. Stevia is a sugar substitute that comes from the leaves of the stevia plant.

Hoffman likes it as an option for people with diabetes because it has less than 1 calorie and no carbs per packet. A study published in the journal Appetite suggests that of the low-calorie sweeteners commonly used by people with diabetes including aspartame and sucrose , stevia was the only one shown to lower blood sugar and insulin levels after a meal.

RELATED: 5 Sugar Substitutes for Type 2 Diabetes. If you find green tea to be too bitter, forgo using honey or table sugar brown or white and instead opt for a sweetener such as stevia.

When drinking green tea, the other thing to keep in mind is caffeine , which can affect blood sugar and blood pressure. The latter is of particular concern for people with type 2 diabetes, who are 2 to 4 times as likely to die of heart disease compared with people without type 2 diabetes, according to the American Heart Association.

A good way to see how you respond to the amount of caffeine in green tea is to check your blood sugar before drinking the tea and then one to two hours afterward, says Smithson. Smithson also recommends using a home blood pressure cuff to monitor blood pressure.

The good news is that green tea has much less caffeine than coffee or black tea. But if your body is sensitive to caffeine, it could still be a problem.

Green tea is made from fresh leaves, which are steamed to prevent fermentation. The tea keeps its green color and antioxidant compounds. Oolong tea is slightly fermented, and black tea is fully fermented.

If you are sensitive to caffeine, herbal teas can be a great substitute. On this note, Arevalo recommends cinnamon tea for people with type 2 diabetes — for both taste and possible health benefits cinnamon is packed with antioxidants.

Health Conditions A-Z. Early diagnosis and treatment helps prevent complications. Learn more. Black tea is a popular beverage worldwide. However, it may also have an effect on health. Learn more about the benefits and risks of drinking black…. A study in mice suggests a potential mechanism that could explain why only some individuals with obesity develop type 2 diabetes.

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Medical News Today. Health Conditions Health Products Discover Tools Connect. Tea and diabetes: Benefits and more. Medically reviewed by Kathy W. Warwick, R. The effects Tea benefits Black tea Green tea Hibiscus tea Turmeric tea Chamomile Lemon balm Risks Summary Tea consumption may be beneficial for people with diabetes.

The effect of tea on diabetes. Benefits of tea for those with diabetes. Black tea. Green tea. Hibiscus tea. Turmeric tea. Lemon balm. Risks of tea for those with diabetes.

Diabetes Type 1 Type 2. How we reviewed this article: Sources. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. We avoid using tertiary references.

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The Ohio Diabbetes University. The team conducted the clinical Green in 40 individuals as a follow-up diabetws Green tea and diabetes study that diagetes lower obesity and fewer Diabetic foot safety risks in mice that consumed green tea supplements Green tea and diabetes Ancient healing practices to gut health. In the new study, green tea extract also lowered blood sugar, or glucose, and decreased gut inflammation and permeability in healthy people — an unexpected finding. Articles on the glucose results and lowered gut permeability and inflammation were published recently in Current Developments in Nutrition. People with metabolic syndrome are diagnosed with at least three of five factors that increase the risk for heart disease, diabetes and other health problems — excess belly fat, high blood pressure, low HDL good cholesterol, and high levels of fasting blood glucose and triglycerides, a type of fat in the blood. Gea details. The results of human clinical trials investigating the effects of green Beta-alanine and muscle power Diabetic foot safety glycemic control diabetez inconsistent. We conducted a anv review and Diabetic foot safety of RCTs that examined the effects of green tea supplementation on glycemic control. A literature search in PubMed, Embase, and Cochrane Library databases for RCTs that investigated the effect of green tea consumption on glycemic control was performed up to February Twenty-seven trials involving subjects were included in the meta-analysis.


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Author: Kisho

2 thoughts on “Green tea and diabetes

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