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Green tea extract for memory

Green tea extract for memory

Values fpr means ± Green tea extract for memory. Baluchnejadmojarad, T. Ageing Res. Frequently asked questions. Article CAS PubMed Google Scholar Download references. Therefore, the main purpose of this study is to analyze the relationship between green tea consumption and cognitive function among middle-aged and elderly people in China.

Green tea extract for memory -

The difference for MoCA score between non-consuming group and tea-consuming group. The MoCA score was higher in the tea-consuming group significantly. MoCA, Montreal Cognitive Assessment scale. Table 4. The cognition differences between the non-consuming group and tea-consuming group.

The results of subgroup analysis were similar to the above difference that was mainly reflected in memory and executive function.

Compared with the non-consumption group, the low group generally had no significant difference. The MoCA scores Probably, higher tea consumption frequency and volume have a stronger protective effect on cognitive function.

Figure 4. The results of subgroup analysis for MoCA scores. Compared with the non-consuming group, the MoCA score gradually increased in the low, medium, and high group, of which there was a significant difference only in the medium and high group, but not in the low group. In terms of anti-oxidative stress, there were significant differences for serum SOD The tea-consuming group had lower serum MDA levels and higher serum SOD and GPx levels, as presented in Table 6 , Figure 5.

Figure 5. The differences in serum AD markers between the non-consuming group and the tea-consuming group. There were significant differences in serum pTau A , Aβ42 C , and total Aβ D levels between the two groups but no difference in serum Aβ40 B levels.

The serum pTau, Aβ42, and total Aβ levels were lower in the tea-consuming group. Aβ, Amyloid-β; pTau, phosphorylated tau Table 6. The biomarker differences between non-consuming group and tea-consuming group. In terms of anti-AD pathology, there were significant differences for serum pTau 3.

The serum pTau , Aβ 42 , and total Aβ levels in the tea-consuming group were lower, as presented in Table 6 and Figure 6. It can be seen that green tea consumption may protect cognitive function by reducing AD pathology and improving anti-oxidative stress capacity.

Figure 6. The differences in serum oxidative stress markers between the non-consuming group and tea-consuming group. There were significant differences in serum SOD A , MDA B , and GPx D levels between the two groups, but no difference in serum GR C levels.

The tea-consuming group had lower serum MDA levels and higher serum SOD and GPx levels. SOD, superoxide dismutase; MDA, Malondialdehyde; GPx, Glutathione peroxidase; GR, Glutathione reductase. The trend of blood marker levels in subgroup analysis was similar to the above but slightly different.

However, in the pairwise comparison for serum GR with the non-consumption group, the high group showed a significant difference The difference in the pairwise comparison was mainly reflected in the medium and high groups, where the serum MDA levels were lower while the SOD, GPx, and GR levels were higher, but no difference in the low group generally.

The difference in the pairwise comparison was also reflected in the medium and high group, where the serum pTau , Aβ 42 , and total Aβ levels were lower. The results were displayed in Table 7 for details. Thus, high consumption of green tea is more likely to affect AD pathology and anti-oxidative stress capacity.

Statistically, significant inverse associations were observed between green tea consumption and mild cognitive impairment in logistic regression analysis, as shown in Table 8 , Figure 7. With the non-consumption group as reference, the crude odds ratios of MCI for different groups were respectively 1.

We included a variety of potential confounders in our multivariate logistic models. However, the results did not change substantially even after adjustment for these variables. Figure 7. The logistic regression analysis between green tea consuming and cognitive impairment.

Statistically, significant inverse associations were observed between green tea consuming and mild cognitive impairment. Model 1: Crude model. Model 2: Adjusted for age, gender, education, smoking history, alcohol consuming, BMI, and physical activity scores. OR, odds ratio; CI, confidence interval.

Table 8. This study found that higher levels of green tea consumption may exert favorable effects on cognitive function and serum biomarkers of AD and oxidative stress in middle-aged and elderly adults. As for the assessment of cognitive function, we used a battery of neuropsychological tests containing 11 scales and covering five prime cognitive domains.

The results demonstrated that the MoCA scores of the tea-consuming group were significantly higher than that of the non-consumption group and were better as the frequency and volume of tea increased. In logistic regression analysis, there was a significant negative correlation between green tea consumption and MCI.

The higher the levels of tea consumption, the lower the risk of cognitive impairment, which suggests that the protective effect of green tea on cognition may be related to frequency and volume.

Furthermore, green tea consumption mainly affected memory and executive function, which was also consistent with the neuropsychological evaluation of vascular cognitive impairment.

The most common impaired cognitive domains in vascular cognitive impairment patients were processing speed and executive function Van der Flier et al. It follows that green tea is likely to be an intervenable vascular protective factor by acting on cerebral blood vessels and its risk factors to achieve the effect of improving cognition.

There have been many reports in the past on the vascular protective effects of green tea. Antioxidants, such as goji berries, green tea, thymus, and so on, may prevent cellular damage by reducing reactive oxygen species ROS overproduction or interfering in reactions that involve ROS.

Increased production of ROS favors vascular dysfunction, inducing altered vascular permeability and inflammation, accompanied by the loss of vascular modulatory function, the imbalance between vasorelaxation and vasoconstriction, and the aberrant expression of inflammatory adhesion molecules Bielli et al.

The mechanism underlying the association between green tea consumption and cognitive function may be concerned with endogenous antioxidant defense and anti-AD pathology.

As mentioned above, previous evidence has indicated that, on the one hand, the intervention of green tea in animal models of cognitive impairment could change the levels of oxidative stress markers such as SOD, MDA, and glutathione and improve spatial learning and memory.

On the other hand, green tea could inhibit the formation of Aβ plaques and Tau, thereby reversing the cognitive impairment of animals. In this study, we selected the seven classic markers both in the two aspects to be detected, adding new evidence to the mechanism demonstration from a clinical perspective.

In terms of anti-oxidative stress, our results were consistent with the past. The intervention of green tea reduced the cytotoxicity of MDA and increased the levels of SOD, GPx, and GR, which were pretty important enzymes to protect the structure and function of cell membranes from damage, indicating that green tea improves the ability to resist oxidative stress.

Oxidative stress, which occurs when there is an imbalance between oxidant and antioxidant levels in the cell resulting in increased ROS production, is another important metabolic facet of AD pathology. Specifically, increased levels of ROS cause damage to macromolecules within the cell, and it is this damage of lipids, proteins, and nucleic acids that gives rise to pathological consequences.

In the brain, ROS are eliminated by the free radical scavenger glutathione GSH through a chemical reaction that converts GSH to its oxidized state.

As such, higher intracellular GSH levels protect cells from ROS-mediated insults. Therefore, regular green tea consumption may improve cognitive function by increasing antioxidant capacity. And the higher the levels of consumption, the stronger the correlation for this mechanism.

A possible explanation is that though the content of Aβ 40 is higher than Aβ 42 in human cerebrospinal fluid and blood, Aβ 42 has stronger toxicity and is easier to aggregate, thus forming the core of Aβ plaques and triggering neurotoxic effects.

So, the sensitivity to drugs or interventions is higher than Aβ It can also be seen from existing research that the mechanism of green tea was more suited to Aβ For example, a molecular dynamics simulation experiment reported that EGCG could change the shape of Aβ 42 through hydrogen bond interactions, damage its molecular dynamics and thereby disrupt Aβ 42 protofibril Zhan et al.

Animal experiments have also revealed that EGCG significantly improved cognitive impairment in aged rats and reduced the formation of Aβ 42 plaques in the brain Wei et al.

In addition, serum pTau demonstrated its potential as an early AD marker once again. It was first discovered that there was an association between serum pTau and green tea consumption, which also provides new ideas for our future research.

In short, regular consumption of green tea may affect the formation of Aβ and Tau and thus protect cognition. In the meanwhile, it has been reported that oxidative stress plays a key role in the pathogenesis of AD.

Antioxidants are compounds that have the ability to counteract the oxidative damage conferred by ROS. Therefore, the antioxidant therapy may provide benefits and halt the progress of AD to advance stages by counteracting neuronal degeneration Walia et al.

In conclusion, our study explored the relationship between green tea consumption and cognitive function among middle-aged and elderly people in China, as well as its anti-AD and oxidative stress effects.

First, we comprehensively reflected on the green tea habits by inquiring about the frequency, the volume, and the years of consumption, and the subjects were divided into several groups accordingly.

Next, the cognition assessment was more diversified. MoCA was used for overall screening that is more sensitive to MCI than the Mini-Mental State Examination scale. The battery of scales covered five prime domains including memory, language, attention, executive function, and visual space.

And the influence of anxiety or depression was also excluded. Moreover, we converted the results of basic research into clinical evidence in the analysis of blood markers and the detection indicators were more comprehensive.

Finally, maybe in contrast to Eastern and Western culture and diet patterns, most orientals are accustomed to long-term green tea consumption, in comparison to coffee in the West. Among the subjects of this study, the average consumption duration in the tea-consuming group was Consequently, the results of our study that green tea consumption was associated with better cognitive function may also be related to the years, adding new evidence to the argument for this issue.

The present study has some limitations. It was a cross-sectional study but determining the impact of diet on cognitive function is a long process. Our findings must be validated in a long-term follow-up study. Our researchers have tried their best to reduce the degree of bias in the process.

If cerebrospinal fluid samples can be collected for analysis, stronger evidence will be obtained in the future. At last, the participants of our study were normal middle-aged and elderly people or those with MCI.

Whether green tea consumption has a protective effect on patients with dementia is not yet known. These also provide us with future research directions. Green tea consumption is associated with better cognitive function, which is mainly reflected in memory and executive function.

It might achieve protective effects by reducing AD-related pathology and improving anti-oxidative stress capacity. And higher levels of tea consumption may have a stronger protective effect on cognitive function.

The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation. The studies involving human participants were reviewed and approved by ClinicalTrials. gov Protocol Registration and Results System PRS ID: NCT RZ: involved in study design, interviewing subjects, and drafting the manuscript.

LZ: involved in study design, data analysis, and revising the manuscript. ZL: involved in collecting blood samples. PZ: involved in assessing cognitive function. HS: involved in detecting biomarkers. D-aY: involved in interviewing subjects.

JC: involved in assessing cognitive function. J-jZ: involved in study design, revising the manuscript, and obtaining funding. This study was supported by National Natural Science Foundation of China grant numbers and , J-jZ. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

We would like to thank for the support of the fund, thank Wuhan University and thank Dr. Jiangtao Yu for his assistance in generating all the figures.

American-Psychiatric-Association Diagnostic and Statistical Manual of Mental Disorders, fifth edition. Washington DC: American Psychiatric Publishing. Google Scholar. Baluchnejadmojarad, T. Chronic epigallocatechingallate ameliorates learning and memory deficits in diabetic rats via modulation of nitric oxide and oxidative stress.

Brain Res. doi: PubMed Abstract CrossRef Full Text Google Scholar. Biasibetti, R. Green tea - epigallocatechingallate reverses oxidative stress and reduces acetylcholinesterase activity in a streptozotocin-induced model of dementia. Bielli, A. Antioxidants and vascular health.

Life Sci. Burckhardt, I. Green tea catechin polyphenols attenuate behavioral and oxidative responses to intermittent hypoxia. Care Med. Farzaei, M. Role of green tea catechins in prevention of age-related cognitive decline: pharmacological targets and clinical perspective.

Cell Physiol. Fischer, K. Nutrients Guo, Q. and Hong, Z. Neuropsychological Assessment , Second Edition. Shanghai: Shanghai Scientific and Technical Publishers.

Ide, K. Effects of green tea consumption on cognitive dysfunction in an elderly population: a randomized placebo-controlled study.

Nutr J. Ishii, S. Identification of the catechin uptake transporter responsible for intestinal absorption of epigallocatechin gallate in mice. Janelidze, S. Jelenkovic, A. Influence of the green tea leaf extract on neurotoxicity of aluminium chloride in rats.

Lee, J. Green tea - -epigallocatechingallate inhibits β-amyloid-induced cognitive dysfunction through modification of secretase activity via inhibition of erk and nf-kappaB pathways in mice.

J Nutr. Liu, Y. The effects of green tea extract on working memory in healthy women. Health Aging. Lopez del Amo, J. Ma, Y. Alzheimers Dis. Noguchi-Shinohara, M. Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline.

PLoS One 9:e Petersson, S. Mediterranean diet, cognitive function and dementia: a systematic review of the evidence. Rezai-Zadeh, K. To date green tea has been linked to a reduced risk of Alzheimer's and certain cancers, improved cardiovascular and oral health, as well as benefits in weight management.

Oolong tea is semi-fermented tea and is somewhere between green and black tea. The four primary polyphenols found in fresh tealeaves are epigallocatechin gallate EGCG , epigallocatechin EGC , epicatechin gallate ECG , and epicatechin EC. The Japanese researchers recruited 12 elderly people with an average age of 88 to participate in their pilot study.

All participants consumed the two grams per day of the green tea powder manufactured by Ito En Ltd for three months. They all took the Mini-Mental State Examination Japanese version MMSE-J at the start and the end of the study.

Results showed that MMSE-J scores improved significantly from an average of Drilling into the data revealed that short term memory in particular was improved. The researchers also reported that triglyceride levels decreased in the participants, but not changes were observed for blood pressure, blood glucose, or cholesterol levels.

Commenting on the potential mechanism of action, the researchers postulated that the anti-oxidative and anti-inflammatory properties of catechins and theanine in green tea may have been behind the benefits.

Ide, H. Yamada, N. Takuma, et al. Show more. Content provided by Fruit d'Or Feb White Paper. Consumers are increasingly interested in the benefits of omegas supplements. According to forecasts for —, the global omega-3 market is expected Content provided by Verdure Sciences Feb White Paper.

Green tea extract for memory fro may help support cognition, maintenance of moderate weight, and anxiety management strategies some protection against Grwen. Green tea extract for memory tea is touted Greem be one memorry the Immunity-boosting lifestyle beverages on the planet that could have many potential health benefits. Green tea contains a type of polyphenol called a catechin. Catechins are antioxidants that help prevent cell damage and provide other health benefits. The most well-known and abundant catechin in green tea is epigallocatechingallate EGCGwhich research has found may be involved in improving various health conditions or markers of disease. Green tea has polyphenol antioxidants, including a catechin called EGCG. These antioxidants could have various beneficial effects on health. Energy boosting substitute This study aimed to examine the effects of green tea extract estract working memory in Green tea extract for memory younger xetract - 29 y and memoty 50 - 63 me,ory women. Green tea extract for memory A single-blind, placebo-controlled, crossover design was used. Setting: A university laboratory. Participants: Twenty non-smoking Caucasian women were recruited in the younger 10 and older 10 age group. Intervention: Subjects received 5. Measurements: Working memory was measured by reading span and N-back task paradigm. Blood sample 20 mL was collected and measured for plasma malondialdehyde MDA and total antioxidant capacity TEAC concentration. Green tea extract for memory

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